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Battling Polyglandular Autoimmune Syndrome with Grace the Unicorn

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A bit about PAS

I have Polyglandular Autoimmune Syndrome Type 2.
Polyglandular autoimmune syndrome (PAS) is made up of a group of autoimmune disorders of the endocrine glands. The syndrome results in failure of the glands to produce their hormones. There is about 1.4-4.5 per 1,000,000 people with PAS.
Stages in the development of Addison disease.
1) Adrenocortical function is lost over a period of years. In the first stage, genetic predisposition is conferred through human leukocyte antigen (HLA) genes.
2)In the second stage, unknown events precipitate anti-adrenal autoimmunity. 3) In the third stage, which involves presymptomatic disease, steroid 21-hydroxylase autoantibodies production predicts future disease.
4) Finally, overt Addison disease develops.
Other common diseases:
Celiac disease
Graves disease
Hashimoto thyroiditis
Type I diabetes mellitus
Abnormality of the musculature
Alopecia
Hypogonadadism
Hypoparathyroidism
Hypopigmented skin patches
Early identification and treatment of another autoimmune endocrine disease may be critical and even life-saving. Currently, management of these disease is restricted to the pharmacological replacement therapy. However, progress in understanding the inner immunological mechanisms implicated in these conditions, should allow common treatments aimed to prevent or at least dampen the progression to irreversible multiple organ damage.
Compared with the background population the risk ratio for death is more than 2-fold higher in patients with Addison’s disease.
Some information taken from:
www.ncbi.nlm.nih.gov
emedicine.medscape.com
academic.oup.com

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